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Second governments can play an important part in
2019-06-26

Second, governments can play an important part in providing incentives for industry to invest in discovering new uses for old drugs. For example, it ARP 100 of could consider the extension of patent protection for old drugs that have found new uses, for example, as embodied in the Hatch-Waxman Act
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br Prior to Zika virus infection
2019-06-26

Prior to 2013–14, Zika virus infection was described as a mild febrile illness with clinical symptoms. However, the emergence of Zika virus in the Pacific and the Americas, the sharp increase in cases of Guillain-Barré syndrome (GBS), and the birth of babies with neurological complications such as
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br Martyn Plummer and colleagues September analyse the
2019-06-26

Martyn Plummer and colleagues (September, 2016) analyse the global burden of cancers attributable to infections in 2012. Despite the relatively low attributable proportion compared with other infectious agents, liver flukes, including and , were estimated to have caused 1300 new cases of cholangi
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br Acknowledgments br Introduction Since
2019-06-26

Acknowledgments Introduction Since the first hospice was established in the United Kingdom in the late 1960s, the use of hospice and palliative care has become popular worldwide. In developed countries, hospice and palliative care are now used for services ranging from in-patient to community/
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For HL most previous studies have shown
2019-06-26

For HL, most previous studies have shown a correlation between decreasing survival rates for patients with HL with decreasing SES, although several studies found no or a varied association between survival outcomes in patients with HL with decreasing SES. The differences in these findings may be att
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NB-598 hydrochloride br Analysis of mismatch repair function
2019-06-26

Analysis of mismatch repair function and results Analysis of microsatellite instability: Multiplex PCR amplification of 5 mononucleotide microsatellite loci was performed using the MSI Analysis System (Promega). Amplification products were analyzed using the ABI 3500Dx capillary electrophoresis i
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Pain flare defined as a temporary worsening of bone pain
2019-06-26

Pain flare, defined as a “temporary worsening of bone pain in the treated metastatic site” [2], has been previously documented as a side effect of radiopharmaceutical and hormonal therapy [2,10,11]. Although it is a recognized side-effect of radiation treatment as well, only recent studies have atte
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br Conflict of interest br
2019-06-26

Conflict of interest Acknowledgment Introduction The majority of clot embolisms associated with atrial fibrillation (AF) are from the left atrial appendage (LAA). Before cardioversion or catheter ablation, clot formation needs to be ruled out traditionally using transesophageal echocardiogr
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Busulfan structure br Genetic basis for atrial standstill br
2019-06-26

Genetic basis for atrial standstill Genetic basis of conduction block Genes involved in cardiac development and bradycardia Development of the CCS is a complex biological process with the potential to be wrought with problems. Several transcription factors, including homeodomain proteins an
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En Introducci n Bases filos ficas del poema Evodio
2019-06-26

En “Introducción. Bases filosóficas del poema” (11-34), Evodio Escalante une los tres hilos de las grandes madejas que considera fundamentales para entender el origen y los alcances de este poema filosófico: Heidegger, Nietzsche y de Gorostiza. La presentación es gradual y va de la mera conexión an
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Florfenicol molecular The Cl HCO anion exchanger AE is
2019-06-26

The Cl−/HCO3− anion exchanger 2 (AE2) is found on cholangiocytes and regulates intracellular pH homeostasis and stimulates bicarbonate secretion. Previous reports have revealed that PBC patients show decreased biliary AE2 expression, and researchers hypothesized that this decrease in AE2 Florfenicol
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The region is also suffering from administrative negligence
2019-06-26

The region is also suffering from administrative negligence, extreme poverty, lack of basic health facilities, and weak infrastructure, which have increased its vulnerability to the climatic misery. Travel time to the nearest health facility is 2–4 h, at a cost of PKR 1000–4000 (US$10–40) in a regio
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Ciertamente Espa a era poco y
2019-06-26

Ciertamente, España era poco y mal conocida. Y ello no sólo ocurría con los radicales europeos, sino también con los latinoamericanos. Creo que la actividad intelectual de La Sagra puede ayudar Budesonide comprender por qué el joven Bilbao que regresa en 1850 del exilio francés ya no es el liberal u
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br Introducci n Los estados son sujetos originarios de
2019-06-26

Introducción Los estados son sujetos originarios de Derecho internacional con plena capacidad. Ejercen su poder de imperio dentro de sus fronteras y, dentro de esos límites, poseen la soberanía de los recursos naturales. Dicho poder de imperio habilita a los países a adoptar políticas conveniente
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O Comit de Reda o
2019-06-26

O Comitê de Redação de Araucaria de Chile, que o integrou permanentemente até sua última publicação em 1990, foi composto pelos seguintes intelectuais chilenos: Luis Bocaz, professor, crítico e ensaísta; Osvaldo Fernández, professor de filosofia; e o jornalista Luis Alberto Mansilla. O economista Al
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