• br A brief history of RBR E s RBR E

  2020-08-03

  

  A brief history of RBR E3s RBR E3s were originally defined based on sequence alignments that predicted a tripartite motif of three zinc (Zn)-binding domains: two RING domains (RING1 and RING2) connected via an in-between-RING (IBR) domain [28], [29]. The prediction together with initial observati

• Phosvitin PV is a highly phosphorylated protein from

  2020-08-03

  

  Phosvitin (PV) is a highly phosphorylated protein from egg yolk (Byrne et al., 1984). Phosvitin and its derived phosvitin hydrolysate (PVH) were reported to exert various physiological activities such as anti-inflammatory activity (Hu et al., 2013, Xu et al., 2012, Young et al., 2011), antioxidant a

• In contrast irinotecan has shown much less myelosuppression

  2020-08-03

  

  In contrast, irinotecan has shown much less myelosuppression and may be more active in Ewing sarcoma both alone and in combination with temozolamide. One phase II study of 13 heavily pretreated Ewing sarcoma patients demonstrated a response rate of 38% including 2 complete responses (Bisogno et al.,

• The present study demonstrates that E coli and

  2020-08-03

  

  The present study demonstrates that E. coli and Taq Pol I DNA polymerases will also facilitate DNA end-joining activity in the absence of DNA synthesis by enhancing the complementary end-joining activity of E. coli DNA ligase when the polymerases are present at sub-stoichiometric concentrations rela

• Variability in response to antipsychotics can be influenced

  2020-08-03

  

  Variability in response to antipsychotics can be influenced by an array of factors, including age, sex, ethnicity, nutritional status, smoking, and alcohol use. There is strong evidence for the role of genetic variability in individual responses to antipsychotic therapy. Advances in pharmacogenetic

• br CK signaling during ischemia in brain

  2020-08-01

  

  CK2 signaling during ischemia in brain GM In GM, CK2 signaling can be either protective or damaging. For example, in a model of transient forebrain ischemia, the preservation or activation of CK2 activity was proposed to be important for neuronal survival after cerebral ischemia [8]. Specifically

• Since CRM itself does not possess any

  2020-07-31

  

  Since CRM1 itself does not possess any RNA binding affinity, an adapter protein is needed for efficient mRNA transport. The RNA-BP HuR has been shown to mediate CRM1-dependent transport for several mRNAs in HeLa Phenacetin [14], [15]. However, in DLD-1 cells, LMB incubation did not change the distr

• Our previous studies showed that PH

  2020-07-31

  

  Our previous studies showed that PH and estradiol administration stimulate ERα expression in the periportal hepatocytes [3,4]. We analyzed estrogen receptors expression during pregnancy (Fig. 3), and ERα RNA expression is induced in the late pregnancy (Fig. 3a and b). Induced-ERα expressed hepatocyt

• br Methods br Results br

  2020-07-31

  

  Methods Results Discussion The present findings that oral preadministration of ONO-8130, a selective prostanoid EP1 receptor antagonist, prevented the cyclophosphamide-induced Otilonium Bromide pain, but had only slight or no effect on the increased bladder weight and vascular permeability

• Resistance exercise RE has been highly recommended by severa

  2020-07-31

  

  Resistance exercise (RE) has been highly recommended by several public health guidelines as a complementary non-pharmacological intervention to decrease cardiac risk factors, which in turn, lowers the incidence of non-communicable diseases and increases lifespan. However, there are no reports evalua

• br Introduction The reticular thalamic nucleus RTn is a thin

  2020-07-31

  

  Introduction The reticular thalamic nucleus (RTn) is a thin shell of neurons that covers the dorsal thalamus and one of the few thalamic nuclei that does not project to the cerebral cortex. Through GABAergic projections, neurons of the RTn synapse with thalamo-cortical neurons (TCs) and regulate

• br Introduction Initially nitrogen mustards NM

  2020-07-31

  

  Introduction Initially, nitrogen mustards (NM) are used as an important military vesicant agent. NM can cause skin inflammation, blisters, and ulcers, as well as eye and respiratory tract damage, with no effective treatment. One of the commonly accepted mechanisms of NMs that causes tissue damage

• A small subset of compounds composed the triazino indole clu

  2020-07-30

  

  A small subset of compounds composed the 5-[1,2,4]triazino[5,6-]indole cluster (). This series of compounds was characterised by a central heterocyclic core with an R1 alkyl amine chain, required for potency (. , , and ), with preference for morpholine over piperidine (. ). The scaffold can be subst

• br Materials and methods br

  2020-07-30

  

  Materials and methods Results Discussion Intra-dPAG microinjections of CRF reduced open arm exploration without affecting general activity (closed-arm entries) in the EPM. This result corroborates previous studies demonstrating that intra-PAG CRF enhances anxiety-like indices in the EPM in

• br Related work The use of cloud

  2020-07-30

  

  Related work The use of cloud-based computing, as previously described in [33], offers a number of advantages for both users and organizations who want to make better use of the resources they manage. Among the benefits identified, that study refers to the use of SaaS, and specifically of MaaS as

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