• Although we observed increases in

  2021-04-28

  

  Although we observed increases in α1-AR mediated cAMP production separately in the nucleus and cytoplasm, compartment specificity was observed for PKA activation. GPCRs and their effector proteins are commonly found in multiprotein signalosomes with A-kinase anchoring proteins (AKAPs) serving as sca

• Finally we have determined for the first time that aromatase

  2021-04-28

  

  Finally, we have determined for the first time that aromatase enzyme activity is necessary to observe IGF-1-dependent U 46619 receptor activation. Neuroestrogen synthesis has been shown to be important for the maintenance of synaptic spine density in hippocampal slice cultures (Kretz et al., 2004)

• br The interaction network between the lncRNAs which have

  2021-04-28

  

  The interaction network between the lncRNAs which have been obtained from the previous steps, VDR and ESR was depicted using Cytoscape tool. Moreover, LncMAP tool (Li et al., 2018) was used to show transcriptional regulatory effects of two lncRNAs (MALAT1 and TBX5-AS1). The interaction network dep

• br Introduction Oral contraceptives OCs

  2021-04-28

  

  Introduction Oral contraceptives (OCs) are the most commonly used medication for contraception all over the world and are also used in the treatment of menstrual disturbances and hyperandrogenism in women with polycystic ovary syndrome [1]. The impact of OC steroids on cardiovascular pathophysiol

• In mammals ribonucleotide reductase RNR is a unique enzyme

  2021-04-28

  

  In mammals, ribonucleotide reductase (RNR) is a unique enzyme that catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleoside triphosphates (dNTPs).7, 8 Mammalian RNR consists of two homodimer subunits: the large catalytic dimer RRM1 and the small regulatory dimer RRM2 or RRM2B. An

• br Results br Discussion We first tested

  2021-04-28

  

  Results Discussion We first tested for any adverse effect of ATR on learning and memory with a MWM test, which is used to assess hippocampal spatial learning and memory abilities in rodents (Vorhees and Williams, 2006). In the place navigation test, the escape latency – or time spent locating

• Another enzyme class that has emerged

  2021-04-28

  

  Another enzyme class that has emerged as a potential alternative to P450s are the so-called ‘unspecific peroxygenases’ (UPOs). They also contain a heme but are extracellularly expressed fungal enzymes that are often more stable than P450 monooxygenases. Importantly, UPOs use H2O2 instead of O2 as t

• In general terms PLA s participate in the Lands

  2021-04-28

  

  In general terms, PLA2s participate in the Lands cycle of phospholipid fatty dna staining recycling [1,15,25], whereby the fatty acid composition at the sn-2 position of phospholipids is tightly controlled by a balance between hydrolytic reactions mediated by PLA2s versus activation of the free fatt

• Our knowledge of DDR induced signaling pathways is still

  2021-04-28

  

  Our knowledge of DDR-induced signaling pathways is still fragmentary. In particular, we do not know which signaling effectors interact with the phosphorylated receptors and how different effectors are linked to the control of specific cellular functions. The DDRs are at the interface between RTKs an

• To elucidate whether the impact of hypoxia on EGFR expressio

  2021-04-28

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer 7ACC1 driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and poorly differen

• What are the molecular signals that guide Tfh

  2021-04-28

  

  What are the molecular signals that guide Tfh cells as they navigate around the lymph node in the course of the immune response? It was recently reported that Tfh cells inside GCs have high expression of SIPR2, which acts to repel them from the S1P-rich lymph in the SCS and promote their retention i

• Several studies have indicated that ICT induces activation

  2021-04-28

  

  Several studies have indicated that ICT induces activation of ERK and p38 kinase in a variety of cells. The ERK pathway was involved in and partly contributed to the neuroprotective effects in rat neuronal arn 509 [14] and anticancer effects in several cancer cells [5], [7], [8]. ICT could also sim

• Birinapant The goal of studying RvE in goblet

  2021-04-28

  

  The goal of studying RvE1 in goblet Birinapant is to determine if it may be used to preserve ocular surface homeostasis and as a treatment of ocular inflammatory diseases. We found that RvE1 increased glycoconjugate secretion after 2 h, not at 4 h. This suggests that RvE1 has a short, but potent, a

• In anticipation of an approach based on modification

  2021-04-28

  

  In anticipation of an approach based on modification of the cyclohexylacetic L 012 sodium salt subunit of 1 as a means of improving permeability, a set of analogs were prepared to map out the optimum display of the acidic functionality. Homologated acids 25 and 26 were found to be equipotent to 1,

• Despite its significance in tumor

  2021-04-27

  

  Despite its significance in tumor suppression, the molecular mechanism by which DAPK is regulated and its interplay with other tumor suppressors and oncoproteins have not been completely unraveled. Although primarily regulated by CaM binding (Cohen et al., 1997), DAPK activity can also be modulated

11046 records 347/737 page Previous Next First page 上5页 346347348349350 下5页 Last page