• As proof of principle the effect of selective blockade

  2021-05-12

  

  As proof of principle, the effect of selective blockade was measured using TAK-044, a peptide antagonist with approximately 250-fold selectivity for the ETA subtype over ETB as measured by ligand binding in the human heart. A 30-mg infusion over 15 minutes of TAK-044 (providing a serum concentration

• For these reasons molecules of the ET family

  2021-05-12

  

  For these reasons, molecules of the ET family and in particular ET-1 are considered useful factors in the evaluation of malignancy and in consequence, in the prognosis for several forms of neoplasia, such as ovarian (Bagnato et al., 2005), prostate (Nelson et al, 1995, Nelson et al, 1996), colorecta

• The host virus coexistence is completely dependent on the ba

  2021-05-12

  

  The host-virus coexistence is completely dependent on the balance between a strong immune response inhibiting virus replication and immune evasion and survival of the virus with periodic shedding to enable transmission to new hosts. In the process of ensuring this balance, the virus manipulates 7TM

• The E enzyme is the apex for downstream

  2021-05-12

  

  The E1 enzyme is the apex for downstream enzymatic cascades and signaling pathways mediated by Ub and Ub-like proteins (Ubls) (Pickart, 2001). Studying characteristics of E1 and its catalytic functions may throw light to the role of ubiquitination in cell development. All known eukaryotic E1 are mon

• It was reported that the expressions of DPP

  2021-05-12

  

  It was reported that the expressions of DPP-4 and SDF-1α increase through HIF-1α [27], [28]. Myocardial ischemia by MI enhanced the DPP-4 and SDF-1α levels in myocardium in the present study. SDF-1α is released from cardiomyocytes and has beneficial effects on cardiomyocytes through SDF-1α/CXCR4 aft

• Compound was advanced to a chronic efficacy study in db

  2021-05-12

  

  Compound 52 was advanced to a chronic efficacy study in db/db mice maintained on a high fat diet. Animals were dosed with 0.5% methylcellulose vehicle, sigma receptor 52 (1, 3 or 15mg/kg, po, Q.D.) or 1 (0.3mg/kg) for 14days. Over the course of the study body weight and food intake were measured da

• Several mechanisms are implicated in

  2021-05-12

  

  Several mechanisms are implicated in lipid-induced insulin resistance in muscle, including oxidative stress (Koves et al., 2008, Zhang et al., 2011, Muoio and Neufer, 2012). Mitochondrion is a major source of ROS production. The oxidation of pyruvate and fatty Prote yielding acetyl-CoA occurs in mi

• The mechanism by which these HIV PIs impair

  2021-05-12

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty poly ic translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular membranes. It

• Yang et al investigatedPsoralidin a

  2021-05-12

  

  Yang et al. investigatedPsoralidin 39, a coumestan derivative isolated from the seed of Psoralea corylifolia, regarding its effects on IR-induced pulmonary inflammation. Psoralidin 39 inhibited the IR-induced COX- 2 expression and PGE(2) production through regulation of PI3K/Akt and NF-κB pathway. A

• Assessment of DNA damage by comet assay

  2021-05-11

  

  Assessment of DNA damage by comet assay and ChEs activity has been widely used as a biomarker of genotoxicity and exposure to pesticide respectively, to measure the risk related to pesticides in the exposed population [15]. Very few studies have explored the association between DNA damage and worker

• br Conflicts of interest br Acknowledgements This

  2021-05-11

  

  Conflicts of interest Acknowledgements This study was funded by Kuwait University Research Administration (Project MI03/10). Introduction Epidemiological, experimental and biologic plausibility support a cardioprotective effect of estrogens in women [1]. Indeed, women are protected until t

• We hypothesize that both IGF dependent kinase activation

  2021-05-11

  

  We hypothesize that both IGF-1-dependent kinase activation and locally synthesized neuroestrogens interactively regulate estrogen receptor activity in neuronal they in the absence of exogenously applied estradiol. The Neuro-2A cell line was chosen as the model system for these studies because IGF-1

• br Materials and methods br Results br Discussion

  2021-05-11

  

  Materials and methods Results Discussion Cells in the human body, especially in the cardiovascular and musculoskeletal systems, undergo a variety of mechanical stimuli. In order to ensure human movement, the strength of stretching muscles acts on cartilage and bone, moving joints through te

• As illustrated in Table monocyclic

  2021-05-11

  

  As illustrated in Table 3, monocyclic yohimbine hydrochloride analogs were synthesized and evaluated. 2-Oxido-3H-1,2,3,5-oxathiadiazol analog 8 showed 15-fold less potent EP1 receptor affinity relative to 2b, while it showed 2.2-fold more potent antagonist activity. Oxadiazole-5-one analog 9 exhibi

• Some natural products such as curcumin resveratrol and sulfo

  2021-05-11

  

  Some natural products, such as curcumin, resveratrol, and sulforaphane, are known to activate Nrf2 in both in vivo and in vitro experimental models where Nrf2-mediated gene 6-Hydroxydopamine hydrobromide plays a crucial protective role [8]. Under basal conditions, Nrf2 binds to Kelch-like ECH-assoc

11111 records 344/741 page Previous Next First page 上5页 341342343344345 下5页 Last page